Premature ovarian failure - Rejuvenate Clinic

Premature Ovarian Failure (POF)

Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a condition where the ovaries stop functioning normally before age 40. This results in menopausal symptoms like hot flashes, night sweats, vaginal dryness, and infertility.

Some key points about POF:

• It affects roughly 1% of women under age 40.
• The cause is often unknown, but can include genetics, autoimmune disorders, cancer treatment, infections, etc.
• Symptoms usually start between ages 15-30.
• Periods become irregular or stop completely. Fertility declines.
• Diagnosis is made with blood tests showing high FSH levels.
• Treatment focuses on relieving symptoms and sometimes preserving fertility. Hormone therapy replaces estrogen and progesterone.

Why does POF happen? Well, no one knows for sure in most cases. Research shows genetics play a role - it runs in families sometimes. Another common cause is autoimmune problems where the immune system attacks the ovaries. Cancer treatments with radiation/chemo can damage ovaries and trigger POF as well.

What is it like living with POF? It's understandably tough for most women. The inability to get pregnant naturally is difficult. Coping with menopausal symptoms like hot flashes in your 20s/30s also severely impacts quality of life. Many experience depression and emotional distress. Support groups and counseling can help.

What are the treatment options? Hormone replacement therapy (HRT) relieves menopausal symptoms when estrogen/progesterone levels drop. HRT pills, patches, gels, implants or injections can be used. Infertility treatment options depend on the woman's age and ovarian reserve, but may include egg or embryo freezing/donation.

While more research on POF is needed, it's encouraging that treatment options exist to manage symptoms and fertility challenges. Increased awareness and support will continue to improve quality of life for those affected.